Tammy Beaumont returns for England's inaugural Lord's Test match against India this July after being left out of the T20 World Cup squad, but there is no place white-ball vice-captain Charlie Dean.
It is understood Dean's workload is being managed following a back injury during the winter with Freya Kemp and Dani Gibson also being rested as all three prioritise the ongoing ICC Women's T20 World Cup.
Nat Sciver-Brunt will become the first English woman to lead out her team in a Test on the famous old ground which hosted its 150th men's Test earlier this month.
There are a group of players boasting a huge range of experience behind Sciver-Brunt - from Somerset's Heather Knight looking to play in her 15th Test, to Surrey duo Alice Capsey and Tilly Corteen-Coleman and Durham's Mady Villiers hoping to make their Test debuts.
Lancashire pair Grace Potts and Ellie Threlkeld will both looking for an England international debut in any format.
The quintet are five of seven players in the squad who did not play in England's most recent Women's Test - against Australia at the Melbourne Cricket Ground in January last year - and joining them are Lancashire's Emma Lamb and Warwickshire's Issy Wong.
The ECB's managing director of women's cricket Clare Connor said: "We have selected a strong Test squad under the leadership of Nat Sciver-Brunt for what will be another historic few days at Lord's for women's cricket.
"Test cricket is a rare and wonderfully challenging experience in the women's game and I know how proud our players are to represent England in this format.
"For the 11 women who will get the chance to be the first to enjoy that feeling at Lord's, it will be a moment to savour."
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through to the final at Lord's on July 5.
